1 What kind of test is it?
LIOFeron® TB/LTBI is an immunological test diagnosing infection with latent tuberculosis, more
scientifically called Latent Tuberculosis Infection (LTBI).
2 Can LIOFeron® TB/LTBI also diagnose active TB?
Yes, but this test similar to all other IGRA tests, cannot differentiate between active TB and LTBI.
3 Have clinical studies been done with LIOFeron® TB/LTBI?
Yes, it has been evaluated in three independent TB hospitals, many more studies are in progress. Please see the published paper on www.lionex.de.
4 What if the QuantiFERON TB Gold Plus and LIOFeron® TB/LTBI results are different?
I such cases, one has to consider results of further tests, such as microscopy, culture, PCR tests, skintest and clinical symptoms.
5 Which antigens Tube is more important for LTBI diagnosis by LIOFeron® TB/LTBI?
The tube containing ANT A proteins.
6 Can we use Instruments, ELISA readers of different manufacturers?
Yes, the current version of LIOFeron® TB/LTBI can be used on any open system.
7- Is there any software to automatically analyse the results of LIOFeron® TB/LTBI?
Yes, we have developed a STAND-ALONE SOFTWARE called LIOFERON®, which can automatically
analyse the results. You can download the LIOFERON software at LIOFERON-SOFTWARE
8 Do we need additional reagents while using the LIOFeron® TB/LTBI kit?
No, all reagents and components are provided with the LIOFeron® TB/LTBI kit (Blood stimulation tubes and ELISA plates).
9 Can we collect blood directly in the LIOFeron® TB/LTBI kit tubes?
No, blood must be collected first in proper Li-Heparin tubes and then dispensed into the tubes provided in the LIOFeron® TB/LTBI kit according to the instructions of use.
10 Are the LIOFeron® TB/LTBI kit tubes, screw-cap blood stimulation tubes?
No, you have to pull the caps to open and press tightly to close the caps.
11 Do we need a CO2 incubator?
Not necessary, but you can use one if available.
12 What is the reason for using IGRA tests in endemic countries, where there is a very high proportion of LTBI?
Such tests are helpful if clinical symptoms indicate active TB, since a positive result of an IGRA test shall confirm infection with MTB to a high degree.
13 Are such IGRA tests useful for population screening with TB-prevalence in mind?
No, such IGRA tests are not specific for active TB and hence, cannot be used for determining prevalence of active TB in a population.
LIOFeron® is a trade mark of LIONEX GmbH, Braunschweig, Germany